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In addition, data obtained in preclinical models and small cohorts suggest that the GLP1RAs liraglutide may downregulate PCSK9, a major inhibitor of LDL-receptor expression associated with the development of atherosclerosis [25, 26]
But, for the most part, patients following standard protocol start with .25mg for the first four weeks and double the dosage in four-week increments until week 13 (e.g., 0.5mg weeks 5-8, 1mg weeks 9-12)
Phua SY, De Smet B, Remacle C, Chan KX, Van Breusegem F
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